Research project

Rahul Sreekumar MRC SIP1 induced epithelial to mesenchymal transition (EMT) promotes metastasis and chemoresistance in colorectal cancer

Research funder:

Medical Research Council
Status:

Not active

Research outputs

The ZEB2-dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes ERCC1 and ERCC4 in colorectal cancer

Rahul Sreekumar, Hajir Al-Saihati, Muhammad Emaduddin, Karwan Moutasim, Massimiliano Mellone, Ashish Patel, Seval Kilic, Metin Cetin, Sule Erdemir, Marta Salgado Navio, Maria Antonette Lopez, Nathan Curtis, Tamer Yagci, John N Primrose, Brendan D. Price, Geert Berx, Gareth J. Thomas, Eugene Tulchinsky, Alex Mirnezami & A. Emre Sayan, 2021, Molecular Oncology , 15(8), 2065-2083

DOI: 10.1002/1878-0261.12965

Type: article

Protein kinase C inhibitors override ZEB1-induced chemoresistance in HCC

Rahul Sreekumar, Muhammad Emaduddin, Hajir Al-Saihati, Karwan Moutasim, James Chan, Marcello Spampinato, Rahul Bhome, Ho Ming Yuen, Claudia Mescoli, Alessandro Vitale, Umberto Cillo, Massimo Rugge, John Primrose, Mohammad Abu Hilal, Stephen Thirdborough, Eugene Tulchinsky, Gareth Thomas, Alex Mirnezami & A Emre Sayan, 2019, Cell Death and Disease, 10(10)

DOI: 10.1038/s41419-019-1885-6

Type: article

Assessment of nuclear ZEB2 as a biomarker for colorectal cancer outcome and TNM risk stratification

Rahul Sreekumar, Scott Harris, Karwan Moutasim, Ricardo DeMateos, Ashish Patel, Katherine Emo, Sophie White, Tamer Yagci, Eugene Tulchinsky, Gareth Thomas, John N Primrose, A Emre Sayan & Alex H Mirnezami, 2018, JAMA Network Open, 1(6), e183115

DOI: 10.1001/jamanetworkopen.2018.3115

Type: article