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Research project

BBSRC Optical Activation of a C.elegans

Project overview

Optogenetic manipulation of C elegans to interrogate neural substrates of behaviour.

Staff

Lead researcher

Professor Lindy Holden-Dye BSc, MSc, PhD, FRSB, FBPhS

PROFESSOR OF NEUROSCIENCES

Research interests

  • Neuropharmacology
  • Invertebrate neuroscience
  • Nematode neurobiology
Connect with Lindy

Email: L.M.Holden-Dye@soton.ac.uk

Other researchers

Professor Vincent O'connor

Professor of Neurochemistry

Research interests

  • Molecular mechanism of synaptic function and dysfunction
  • Synaptic degeneration
  • Genetic models of synaptic and neuronal dysfunction
Connect with Vincent

Email: V.M.OConnor@soton.ac.uk

Research outputs

Yeast two-hybrid screening identifies MPZ-1 and PTP-1 as candidate scaffolding proteins of metabotropic glutamate receptors in Caenorhabditis elegans
James Dillon, Lindy Holden-Dye & Vincent O’Connor, 2018, Invertebrate Neuroscience, 18(4), 1-12
DOI: 10.1007/s10158-018-0218-2
Type: article
Metabotropic glutamate receptors: modulators of context-dependent feeding behaviour in C. elegans
James Dillon, Christopher Franks, Caitriona Murray, Richard J. Edwards, Fernando Calahorro, Takeshi Ishihara, Isao Katsura, Lindy Holden-Dye & Vincent O’Connor, 2015, The Journal of Biological Chemistry, 290(24), 15052-15065
DOI: 10.1074/jbc.M114.606608
Type: article
NeuroChip: a microfluidic electrophysiological device for genetic and chemical biology screening of Caenorhabditis elegans adult and larvae
Chunxiao Hu, James Dillon, James Kearn, Caitriona Murray, Vincent O'Connor, Lindy Holden-Dye & Hywel Morgan, 2013, PLoS ONE, 8(5), e64297-[17pp]
DOI: 10.1371/journal.pone.0064297
Type: article
Selective toxicity of the anthelmintic emodepside revealed by heterologous expression of human KCNMA1 in caenorhabditis elegans
Anna Crisford, Caitriona Murray, Vincent O'Connor, Richard J. Edwards, Nina Kruger, Claudia Welz, Georg von Samson-Himmelstjerna, Achim Harder, Robert J. Walker & Lindy Holden-Dye, 2011, Molecular Pharmacology, 79(6), 1031-1043
DOI: 10.1124/mol.111.071043
Type: article
A comparison of electrically evoked and channel rhodopsin-evoked postsynaptic potentials in the pharyngeal system of Caenorhabditis elegans
Christopher J. Franks, Caitriona Murray, David Ogden, Vincent O'Connor & Lindy Holden-Dye, 2009, Invertebrate Neuroscience, 9(1), 43
DOI: 10.1007/s10158-009-0088-8
Type: article