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Research project

Mechanisms of long-range retrograde signal propogation - Deinhardt - BBSRC

Staff

Lead researcher

Professor Katrin Deinhardt

Professor

Research interests

  • Short- and long-range neurotrophin signalling and its role in morphological plasticity
  • Early neuronal dysfunction in disturbed proteostasis
  • Cellular mechanisms that underlie tau propagation across neurons
Connect with Katrin

Email: K.Deinhardt@soton.ac.uk

Collaborating research institutes, centres and groups

Neuroscience

We work on national and global priorities of health and well-being, underpinning research in neuroscience, and age-related neurodegenerative diseases, including Alzheimer’s.

Research outputs

A primate-specific short GluN2A-NMDA receptor isoform is expressed in the human brain
Mariana Vargas-Caballero, Hannah, Kate Warming, Chrysia-Maria Pegasiou, Aleksandra, Paulina Pitera, Hanna Kariis, Steven Houghton, Ksenia Kurbatskaya, Aminul Ahmed, Paul Grundy, Girish V. Vajramani, Diederik Bulters, Xavier Altafaj & Katrin Deinhardt, 2019, Molecular Brain , 12(1), 1-8
DOI: 10.1186/s13041-019-0485-9
Type: article
Asymmetric confinement for defining outgrowth directionality
Paul Holloway, Grace Hallinan, Manjunath Hegde, Simon I.R. Lane, Katrin Deinhardt & Jonathan West, 2019, Lab on a Chip, 19(8), 1484-1489
DOI: 10.1039/c9lc00078j
Type: article
Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer’s disease
Sarmi Sri, Chrysia-Maria Pegasiou, Chantal-Abbigail Cave, Katie Hough, Natalie Wood, Diego Gomez-Nicola, Katrin Deinhardt, David Bannerman, Victor Perry & Mariana Vargas-Caballero, 2019, Acta Neuropathologica Communications, 7(25)
DOI: 10.1186/s40478-019-0670-1
Type: article
Minimalistic in vitro systems for investigating tau pathology
Grace Hallinan, Aleksandra, Paulina Pitera, Prutha Patel, Jonathan West & Katrin Deinhardt, 2018, Journal of Neuroscience Methods
DOI: 10.1016/j.jneumeth.2018.09.032
Type: review
Mechano-sensitization of mammalian neuronal networks through expression of the bacterial mechanosensitive MscL channel
Alessandro Soloperto, Anna Boccaccio, Andrea Contestabile, Monica Moroni, Grace Hallinan, Gemma Palazzolo, John Chad, Katrin Deinhardt, Dario Carugo & Francesco Difato, 2018, Journal of Cell Science, 131(5)
DOI: 10.1242/jcs.210393
Type: article