View all research projects
Research project

Investigating local determinants of outcome in human tuberculosis

Project overview

This project investigates why some TB lesions progress while some regress by utilising single cell sequencing analysis of our 3D cell culture model of infection, along with engineered real-time readouts. Parallel analysis of clinical samples aims to identify new therapeutic targets.

Staff

Lead researchers

Professor Paul Elkington

Director of Inst. for Medical Innovation
Research interests
  • tuberculosis
  • immunopathology
  • diagnosis
Connect with Paul

Email: P.Elkington@soton.ac.uk

Other researchers

Professor Hywel Morgan MBE

Professor of Bioelectronics
Research interests
  • Microfluidics
  • Bio-sensors
  • Lab-on-a-chip technologies
Connect with Hywel

Email: hm@ecs.soton.ac.uk

Dr Liku Tezera BM, MSc , PhD, FHEA

Senior Research Fellow
Research interests
  • Physiologically relevant in vitro models for chronic bacterial infections that capture host m…
Connect with Liku

Email: L.Tezera@soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

Single-cell and spatial profiling reveals a role for tuberculosis-induced myofibroblasts in lung immunopathology
Ian Mbano, Nuo Liu, Mark Wardsworth II, Mark Chambers, Thabo Mpotje, Osaretin Asowata, Sarah Nyquist, Kievershen Nargan, Duran Ramsuran, Farina Karim, Travis Hughes, Joshua Bromley, Robert Krause, Liku Tezera, Michaela T Reichmann, Sharie Keanne Ganchua, Pauline Maiello, Edward Klein, Henrik Kloverpris, Kaylesh Dullabh, Rajhmun Madansein, Sergio Triana, Adrie Steyn, Bonnie Berger, Mohlopheni Marakalala, Sarah Fortune, Joanne Flynn, Paul Elkington, Alex Shalek & Alasdair Leslie, 2025, The Journal of Experimental Medicine
Type: article
Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10
Mohamed Ahmed, Jared Mackenzie, Liku Bekele Tezera, Robert Krause, Barry Truebody, Diana Garay Baquero, Andres Vallejo Pulido, Katya Govender, John Adamson, Hayden Fisher, Jonathan W. Essex, Salah Mansour, Paul Elkington, Adrie J. C. Steyn & Alasdair Leslie, 2022, Communications Biology, 5(1317)
DOI: 10.1038/s42003-022-04265-0
Type: article