Research project

TISuMR: Integrated Tissue Slice Culture and NMR Metabolomics – A Novel Approach Towards Systemic

Research groups:
Lead researchers:

Professor Marcel Utz
Research funder:

European Union
Status:

Not active

Project overview

This international collaboration, led by Southampton, aims to provide a radically new technological platform for the integrated culture and NMR observation of liver tissue slices, with the immediate objective to elucidate the mechanism of liver damage by cholestasis.

Staff

Lead researchers

Professor Marcel Utz

Professorial Fellow-Research

Research interests

Integration of microfluidic lab-on-a-chip technology with NMR spectroscopy and imaging;
Behaviour of complex materials.

Connect with Marcel

Email: Marcel.Utz@soton.ac.uk

Collaborating research institutes, centres and groups

Magnetic Resonance

Our main focus is finding ways to extend the timescale over which magnetic resonance can be made.

Research outputs

Fully automated characterization of protein-peptide binding by microfluidic 2D NMR

Marek Plata, Manvendra Sharma, Marcel Utz & Jörn M. Werner, 2022, Journal of the American Chemical Society, 145(5), 3204–3210

DOI: 10.1021/jacs.2c13052

Type: article

Time-resolved non-invasive metabolomic monitoring of a single cancer spheroid by microfluidic NMR

Bishnubrata Patra, Manvendra Sharma, William G Hale & Marcel Utz, 2021, Scientific Reports, 11(1)

DOI: 10.1038/s41598-020-79693-1

Type: article

Synergies between hyperpolarized NMR and microfluidics: a review

James Eills, William G Hale & Marcel Utz, 2021, Progress in Nuclear Magnetic Resonance Spectroscopy

DOI: 10.1016/j.pnmrs.2021.09.001

Type: review

Microfluidic platform for serial mixing experiments with in operando nuclear magnetic resonance spectroscopy

Marek Plata, William G Hale, Manvendra Sharma, Jorn Werner & Marcel Utz, 2021, Lab on a Chip, 21(8), 1598-1603

DOI: 10.1039/D0LC01100B

Type: article

Kinetic investigation of a cucurbit[7]uril-based pseudo[6]rotaxane system by microfluidic nuclear magnetic resonance

Yibin Sun, Hongxun Fang, Xujing Lin, Xiuxiu Wang, Ganyu Chen, Xinchang Wang, Zhongqun Tian, Liulin Yang, Marcel Utz & Xiaoyu Cao, 2021, Chemistry, 2021(3), 948–956

DOI: 10.31635/ccschem.021.202100773

Type: article