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Research project

Establishment of a National Network on Musculoskeletal Ageing

Staff

Lead researcher

Professor Cyrus Cooper

Prof Rheumatology Clinical Epidemiology

Research interests

  • Key research contributions have been:
  • discovery of the developmental influences which contribute to the risk of osteoporosis and hip fracture in late adulthood
  • demonstration that maternal vitamin D insufficiency is associated with sub-optimal bone mineral accrual in childhood
Connect with Cyrus

Email: cc@mrc.soton.ac.uk

Other researchers

Professor Nicholas Harvey

Director/Professor

Research interests

  • Lifecourse epidemiology of osteoporosis and fragility fractures
  • Understanding mechanism and development of novel interventions across lifecourse to prevent fragility fractures
Connect with Nicholas

Email: nch@mrc.soton.ac.uk

Collaborating research institutes, centres and groups

Interdisciplinary Musculoskeletal Health

The University hosts a substantial interdisciplinary community of researchers working to transform musculoskeletal health across the life course.

Research outputs

Potential adverse effect of non-steroidal anti-inflammatory drugs (NSAIDs) on bisphosphonate efficacy: an exploratory post hoc analysis from a randomized controlled trial of clodronate
Z. Zheng, Helena Johansson, Nicholas Harvey, M. Lorentzon, Lisbeth Vandenput, E. Liu, J A. Kanis & E. V. McCloskey, 2022, Journal of Bone and Mineral Research, 37(6), 1117-1124
DOI: 10.1002/jbmr.4548
Type: article
Update of the fracture risk prediction tool FRAX: A systematic review of potential cohorts and analysis plan
Lisbeth Vandenput, H. Johansson, E. V. McCloskey, E. Liu, Kristina E. Akesson, F.A. Anderson, R. Azagra, C.L. Bager, Charlotte Beaudart, H.A. Bischoff-Ferrari, E. Biver, Olivier Bruyère, J.A. Cauley, J.R. Center, R. Chapulat, C. Christiansen, Cyrus Cooper, Carolyn J. Crandall, Steven Cummings, J.A.P. da Silva, Bess Dawson-Hughes, A. Diez-Pérez, Alyssa B. Dufour, J.A. Eisman, Petra J.M. Elders, S. Ferrari, Y. Fujita, S. Fujiwara, C.C. Glüer, I. Goldstein, D. Goltzman, V. Gudnason, J. Hall, D. Hans, M. Hoff, Rosemary J. Hollick, Martijn Huisman, M. Iki, S. Ish-Shalom, G. Jones, M.K. Karlsson, Sundeep Khosla, D.P. Kiel, W-P Koh, F. Koromani, M.A. Kotowicz, H. Kroger, T. Kwok, Olivier Lamy, Arnulf Langhammer, Bagher Larijani, Kurt Lippuner, D Mellström, Thomas Merlijn, A. Nordstrom, P. Nordstrom, T.W. O'Neill, B. Obermayer-Piestch, Nicholas Harvey, J A. Kanis, C. Ohlsson, E.S. Orwoll, J.A. Pasco, F. Rivadeneira, B. Schei, A.M. Schott, E.J. Shiroma, K. Siggeirsdottir, E.M. Simonsick, E. Sornay-Rendu, R. Sund, K.M.A. Swart, P. Szulc, J. Tamaki, D.J. Torgerson, N.M. Van Schoor, T.P. van Staa, J.C. Vilas, N.J Wareham, N.C. Wright, N. Yoshimura, M.C. Zillikens, M. Zwart, M. Lorentzon & W.D. Leslie, 2022, Osteoporosis International, 33(10), 2103-2136
DOI: 10.1007/s00198-022-06435-6
Type: review
Early life vitamin D depletion and mechanical loading determine methylation changes in the RUNX2, RXRA, and osterix promoters in mice
Nevena Krstic, Nick Bishop, Elizabeth Curtis, Cyrus Cooper, Nicholas Harvey, Karen Lillycrop, Robert Murray, Robert Owen, Gwen Reilly, Tim M. Skerry & Steph Borg, 2022, Genes & Nutrition, 17(1)
DOI: 10.1186/s12263-022-00711-0
Type: article
Time for revival of bone biopsy with histomorphometric analysis in chronic kidney disease (CKD): moving from skepticism to pragmatism.
Maria Fusaro, Giulia Vanessa Re Sarto, Maurizio Gallieni, Laura Cosmai, Pieregiorgio Messa, Maurizio Rossini, Iacopo Chiodini, Mario Plebani, Pieter Evenepoel, Nicholas Harvey, S. Ferrari, Jorge B Cannata-Andía, Andrea  Trombetti, Maria Luisa Brandi, Markus Ketteler, Thomas L. Nickolas, John Cunningham, Syazrah Salam, Carlo Della Rocca, Aldo Scarpa, Salvatore Minisola, Fabio Malberti, Filomena Cetani, Mario Cozzolino, Sandro Mazzaferro, Luigi Morrone, Giovanni Tripepi, Martina Zaninotto, Maria Cristina Mereu, Maura Ravera, Giuseppe Cianciolo, Gaetano La Manna, Andrea Aghi, Sandro Giannini & Luca Dalle Carbonare, 2022, Nutrients, 14(9)
DOI: 10.3390/nu14091742
Type: review
The effect of fracture recency on observed 10-year fracture probability: a registry-based cohort study
William D. Leslie, Suzanne N Morin, Lisa M. Lix, Eugene V. McCloskey, Helena Johansson, Nicholas Harvey & John A. Kanis, 2022, Journal of Bone and Mineral Research, 37(5), 848-855
DOI: 10.1002/jbmr.4526
Type: article