Research project

Role of autophagy in oncogenic RAS-induced invasive behaviour

Research groups:
Lead researchers:

Dr Yihua Wang
Research funder:

Royal Society
Status:

Not active

Project overview

Autophagy, a key survival mechanism allowing cells to tolerate stress or lack of nutrients, promotes tumourigenesis, in particular in RAS-mutated cancer. We demonstrated that elevated autophagy activity bypasses oncogenic RAS-induced senescence in order to support tumour growth (PNAS 2012). This project aims to comprehensively study the role of autophagy in oncogenic RAS-induced tumour invasion.