Research Research groups Member of: Clinical Neurosciences Research projects Active projects Medium through-put drug discovery for albinism Researchers: Doctor Eloise Keeling Doctor James Self Sponsor: Fight for Sight Publications 22 publications Page 2 of 3 Oligomeric Aβ1-42 induces an AMD-like phenotype and accumulates in lysosomes to impair RPE function Savannah A. Lynn, David A. Johnston, Jenny A. Scott, Rosie Munday, Roshni S. Desai, Eloise Keeling, Ruaridh Weaterton, Alexander Simpson, Dillon Davis, Thomas Freeman, David S. Chatelet, Anton Page, Angela J. Cree, Helena Lee, Tracey A. Newman, Andrew J. Lotery & J. Arjuna Ratnayaka, 2021, Cells, 10(2), 1-30 DOI: 10.3390/cells10020413 Type: article 3D-reconstructed retinal pigment epithelial cells provide insights into the anatomy of the outer retina Eloise Keeling, David S. Chatelet, Nicole Y. T. Tan, Farihah Khan, Rhys Richards, Thibana Thisainathan, Patricia Goggin, Anton Page, David A. Tumbarello, Andrew J. Lotery & J. Arjuna Ratnayaka, 2020, International Journal of Molecular Sciences, 21(21) DOI: 10.3390/ijms21218408 Type: article An in-vitro cell model of intracellular protein aggregation provides insights into RPE stress associated with retinopathy Eloise Keeling, Annabelle J Culling, David A Johnston, David S Chatelet, Anton Page, David A Tumbarello, Andrew J Lotery & J Arjuna Ratnayaka, 2020, International Journal of Molecular Sciences, 21(18) DOI: 10.3390/ijms21186647 Type: article Oxidative stress and dysfunctional intracellular traffic linked to an unhealthy diet results in impaired cargo transport in the Retinal Pigment Epithelium (RPE) Eloise Keeling, David Chatelet, David Johnston, Anton Page, David Tumbarello, Andrew Lotery & J. Arjuna Ratnayaka, 2019, Molecular Nutrition & Food Research, 63(15) DOI: 10.1002/mnfr.201800951 Type: article A lasered mouse model of retinal degeneration displays progressive outer retinal pathology providing insights into early geographic atrophy Paul Ibbett, Srinivas V. Goverdhan, Elena Pipi, Joe Kirit Chouhan, Eloise Keeling, Elizabeth M. Angus, Jenny Scott, Maureen Gatherer, Anton Page, Jessica Teeling, Andrew Lotery & J. Arjuna Ratnayaka, 2019, Scientific Reports, 9 DOI: 10.1038/s41598-019-43906-z Type: article Study of intracellular cargo trafficking and co-localization in the phagosome and autophagy-lysosomal pathways of Retinal Pigment Epithelium (RPE) cells J. Arjuna Ratnayaka, Eloise Keeling & David Chatelet, 2019 DOI: 10.1007/7651_2019_223 Type: bookChapter The role of high-fat diet and oxidative stress in driving the structural and functional deficits associated with Age-related Macular Degeneration Eloise Keeling, 2019 Type: thesis A convenient protocol for establishing a human cell culture model of the outer retina. Savannah A. Lynn, Eloise Keeling, Jennifer Dewing, David Johnston, Anton M. Page, Angela Cree, David Tumbarello, Tracey Newman, Andrew Lotery & J. Arjuna Ratnayaka, 2018, F1000Research, 7 DOI: 10.12688/f1000research.15409.1 Type: article Lysosomal impairment in the Retinal Pigment Epithelium (RPE) - a pathway of damage in the ageing retina Eloise Keeling, David Johnston, David Chatelet, David Tumbarello, Andrew Lotery & J. Arjuna Ratnayaka, 2018, Investigative Ophthalmology & Visual Science, 59 , 4487 Type: conference Ex-vivo models of the Retinal Pigment Epithelium (RPE) in long-term culture faithfully recapitulate key structural and physiological features of native RPE Savannah Lynn, Gareth Ward, Eloise Keeling, Jenny Scott, Angela J. Cree, David A. Johnston, Anton Page, Enrique Cuan Urquizo, Atul Bhaskar, Martin C. Grossel, David A. Tumbarello, Tracey A. Newman, Andrew J. Lotery & J. Arjuna Ratnayaka, 2017, Tissue and Cell, 49(4), 447-460 DOI: 10.1016/j.tice.2017.06.003 Type: article Pagination Previous page Previous 1 2 3 Next page Next