Research project

Core Capability for Chemistry Research in Southampton - Brown - EPSRC

Lead researcher:

Professor Richard Brown
Other researchers:

Professor Gill Reid
Research funder:

EPSRC
Status:

Not active

Staff

Lead researcher

Professor Richard Brown

Professor of Organic Chemistry

Connect with Richard

Email: R.C.Brown@soton.ac.uk

Other researchers

Research interests

Synthetic inorganic chemistry
Design and synthesis of new macrocyclic and multidentate ligands involving donor atoms from Groups 15 (P, As, Sb, Bi) and 16 (S, Se, Te)
Coordination chemistry with s-, p-, d- and f-block metal ions

Connect with Gill

Email: G.Reid@soton.ac.uk

Research outputs

Discovery of Nanomolar-Affinity Pharmacological Chaperones Stabilizing the Oncogenic p53 Mutant Y220C

Joseph Richard Stephenson Clarke, Leon R Douglas, Patrick Duriez, Dimitrios-Ilias Balourdas, Andreas C. Joerger, Raniya Khadiullina, Emil Bulatov & Matthias G.J. Baud, 2022, ACS Pharmacology and Translational Science, 5(11), 1169–1180

DOI: 10.1021/acsptsci.2c00164

Type: article

Cathodic radical cyclisation of aryl halides using a strongly-reducing catalytic mediator in flow

Ana Folgueiras Amador, Alexander Teuten, Mateo Salam Perez, James Pearce, Guy Denuault, Derek Pletcher, Phillip James Parsons, David C. Harrowven & Richard C.D. Brown, 2022, Angewandte Chemie International Edition, 61(35)

DOI: 10.1002/anie.202203694

Type: article

Biophysical survey of small-molecule β-catenin inhibitors

Michael, Arron McCoy, Dominique Spicer, Neil J. Wells, Kurt Hoogewijs, Marc Fiedler & Matthias G.J. Baud, 2022, Journal of Medicinal Chemistry, 65(10), 7246–7261

DOI: 10.1021/acs.jmedchem.2c00228

Type: article

Wavelength dependent photoextrusion and tandem photoextrusion reactions of ninhydrin bis-acetals for the synthesis of 8-ring lactones, benzocyclobutenes and orthoanhydrides

David C. Harrowven, Wei Sun, Surajit Kayal, William Raimbach, Xue-Zhong Sun, Mark Light, Magnus W.D. Hanson-Heine & Michael W George, 2021, ChemComm

DOI: 10.1039/D1CC06800H

Type: article

Relating Conformational Equilibria to Conformer-Specific Lipophilicities: New Opportunities in Drug Discovery

2021, Angewandte Chemie, 61(7)

DOI: 10.1002/anie.202114862

Type: article