Antibiotic resistance

Over the course of 11 days, Escherichia coli bacteria evolved resistance to a 1,000-fold increase in concentration of the antibiotic trimethoprim above its minimum inhibitory concentration.

Baym, M., Lieberman, T. D., Kelsic, E. D., Chait, R., Gross, R., Yelin, I., and Kishony, R. (2016) Spatiotemporal microbial evolution on antibiotic landscapes. Science. doi: https://doi.org/10.1126/science.aag0822.

Timeline of the Human Condition, CE 1928