University of Southampton

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Announcements

MSc in Biomedical Engineering started October 2016. For further details, contact n.w.bressloff@soton.ac.uk

July 2017

The ArterioSorb(TM) bioresorbable stent designed in Southampton. See page 8.

May 2017

EuroPCR 2017, Paris.

April 2017

MedTech Strategist Innovation Summit, Dublin.

March 2017

Carena Healthcare, Southampton Science Park Catalyst Graduation.

Prelim

These pages were first created in April 2011.

Prof Neil W. Bressloff

Research

Biomedical Devices Biomedical engineering device optimisation tool Coronary artery image fusion Design Strategies

Publications

Diem, A.K. et. al. 2017, Arterial pulsations cannot drive intramural periarterial drainage: significance for a-beta drainage. Frontiers in Neuroscience. 11(9), 475. http://journal.frontiersin.org/article/10.3389/fnins.2017.00475/full

Diem, A.K. & Bressloff, N.W., 2017. VaMpy: A Python Package to Solve 1D Blood Flow Problems. Journal of Open Research Software. 5(17). DOI: http://doi.org/10.5334/jors.159

Bailey, J., Curzen, N. and Bressloff, N. W., 2017. The Impact of Imperfect Frame Deployment and Rotational Orientation on Stress within the Prosthetic Leaflets During Transcatheter Aortic Valve Implantation. J. Biomech. 53: 22-28. http://dx.doi.org/10.1016/j.jbiomech.2016.12.031.

Diem, A., Tan, M., Bressloff, N. W., Hawkes, C., Morris, A. W. J., Weller, R. O. and Carare, R. O., 2016 A Simulation Model of Periarterial Clearance of Amyloid-Beta from the Brain Front. Aging Neuro. Final version at http://dx.doi.org/10.3389/fnagi.2016.00018

Ragkousis, G., Curzen, N. and Bressloff, N. W., 2016. Multi-objective optimisation of stent dilation strategy in a patient-specific coronary artery via computational and surrogate modeling. J. Biomech.. 49(2):205-215. Final version at http://dx.doi.org/10.1016/j.jbiomech.2015.12.013

Bailey, J., Curzen, N. and Bressloff, N. W., 2016. Assessing the impact of including leaflets in the simulation of TAVI deployment in to a patient specific aortic root. Comp. Meth. in Biomech. and Biomed. Eng. 19(7): 733-744. The final publication is available at Taylor & Francis via http://www.tandfonline.com/doi/pdf/10.1080/10255842.2015.1058928 or as author's pdf: Bailey_LeafletsTAVI_Comp_Meth_Biomech_BME_2015

Bressloff, N. W., Ragkousis, G. and Curzen, N., 2016. Design optimisation of coronary artery stent systems. Annals. Biomed. Eng. 44(2): 357-367. Final version at Springer http://dx.doi.org/10.1007/s10439-015-1373-9 or author's pdf: Bressloff_DesignOptimCoronaryArteryStentSystems_ Annals_Biomed_Eng_2015

Morris, P. D. et al. & Gunn, J. P., 2015. Computational fluid dynamics modelling in cardiovascular medicine. Heart doi:10.1136/heartjnl-2015-308044.Open access.

Berg, P. et al. & Janiga, G., 2015. The Computational Fluid Dynamics Rupture Challenge 2013 - Phase II: Variability of Hemodynamic Simulations in Two Intracranial Aneurysms. J. Biomed. Eng. 137, 121008/121001-121008/121013. Access here.

Leyva-Mendivil, M. F., Page, A., Bressloff, N. W. and Limbert, G., 2015. A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin. J Mech. Behav. Biomed. Mat. 49: 197-219. Final version avaialable here:http://dx.doi.org/10.1016/j.jmbbm.2015.05.010

Dubas, A., Bressloff, N. W. and Abu-Sharkh, S., 2015. Numerical Modelling of Rotor-Stator Interaction in Rim Driven Thrusters. Ocean Engineering, 106: 281-288.

Ragkousis, G., Curzen, N. and Bressloff, N. W., 2015. Computational modelling of multi-folded balloon delivery systems for coronary artery stenting: Insights into patient-specific stent malapposition Annals. Biomed. Eng., 43(8):1786-1802. DOI: 10.1007/s10439-014-1237-8. The final publication is available at Springer via http://dx.doi.org/10.1007/s10439-014-1237-8 or as author's pdf: Ragkousis_TaperedBalloonsCoronaryStents_ABME_2015

Bressloff, N. W., 2014, Multi-objective design of a biodegradable coronary artery stent, Cardiovascular and Cardiac Therapeutic Devices in the Springer series "Studies in Mechanobiology, Tissue Engineering and Biomaterials", Ed. Tom Franz, ISBN 978-3-642-53835-3.

Ragkousis, G., Curzen, N. and Bressloff, N. W., 2014, Simulation of longitudinal stent deformation in a patient-specific coronary artery Med. Eng. Phys., 36(4): 467-476, Available online at http://dx.doi.org/10.1016/j.medengphy.2014.02.004 or as author's pdf: Ragkousis_LSD_Med_Eng_Phys_2014

Gregory, J. et al., 2014, Prometheus: A Geometry-Centric Optimization System for Combustor Design Proc. ASME Turbo Expo 2014: Turbine Technical Conference and Exposition, June 16-20th, Dusseldorf, Germany, 2014.

Alidousti, H., Taylor, M. and Bressloff, N. W., 2014, Periprosthetic wear particle migration and distribution modelling and the implication for osteolysis in cementless total hip replacement J. Mech. Behav. Biomed. Mat., 32: 225-244.

Steinman, D. A. et al, 2013, Variability of CFD solutions for pressure and flow in a giant aneurism, J. Biomech. Eng., 135(2): 021016.

Carugo, D. Capretto, L., Nehru, E., Mansour, M., Smyth, N., Bressloff, N.W. & Zhang, X., 2013, A microfluidic-based arteriolar network model for biophysical and bioanalytical investigations, Curr. Anal. Chem., 9(1): 47-59.

Bressloff, N. W., Pant, S., Al-Lamee, K. Multi-objective design refinement of coronary stents. ECCOMAS 2012 (6th European Congress on Computational Methods in Applied Sciences and Engineering), September 10 - 14, 2012, Vienna, Austria.

Pant, S., Bressloff, N. W. and Limbert, G., 2012, Geometry parameterization and multidisciplinary constrained optimisation of coronary stents, Biomechics and Modeling in Mechanobiology, 11(1): 61-82, (doi: 10.1007/s10237-011-0293-3).

Nurdin, A., Bressloff, N. W., Keane, A. J. and Holden, C. M. E., 2012, Shape optimisation using CAD linked free-form deformation, The Aeronautical Journal, 116(1183): 915-939.

Wankhede, M. J., Bressloff, N. W. and Keane, A. J., 2012, A time-parallel CFD approach for unsteady combustor flow analysis and design optimisation. GT2012-68164, ASME Turbo Expo 2012, Copenhagen, Denmark.

Alidousti, H., Taylor, M. and Bressloff, N. W., 2012, Do capsular pressure and implant motion interact to cause high pressure in the periprosthetic bone in cementless total hip replacement? ORS, 0227, 2012, San Francisco.

Bressloff, N.W., Pant, S. and Al-Lamee, K.G, 2012, A stent, PCT Patent WO143731.

Pant, S., Limbert, G., Curzen, N. and Bressloff, N. W. , 2011, Multi-objective design optimisation of coronary stents, Biomaterials, 32: 7755-7773. Leading Opinion Paper. Final version at Elsevier http://dx.doi.org/10.1016/j.biomaterials.2011.07.059 or author's pdf: Pant_MultiobjectiveDesignCoronaryStents_Biomat_2011

Alidousti, H., Taylor, M. and Bressloff, N. W., 2011, Do capsular pressure and implant motion interact to cause high pressure in the periprosthetic bone in total hip replacement? ASME J. Biomech. Eng., 133(12): 1-10.

Dubas, A., Bressloff, N. W., Fanghor, H. and Abu-Sharkh, S., 2011, Computational fluid Dynamics simulation of a rim driven thruster, Open Source CFD Conference 2011.

Wankhede, M. J., Bressloff, N. W. and Keane, A. J., 2011, Combustor design optimisation using co-Kriging of steady and unsteady turbulent combustion, GTP-11-1113, Journal of Engineering for Gas Turbines and Power, 133(12), (doi:10.1115/1.4004155).

Ursache, N. M., Bressloff, N. W. and Keane, A. J., 2011, Aircraft roll enhancement via multi-objective optimization using surrogate modelling, AIAA J., 49(7): 1525-1541.

Wankhede, M. J., Bressloff, N. W., Keane, A. J. and Zedda, M., 2011, Combustor design optimisation using co-Kriging of steady and unsteady turbulent combustion, GT2011-46420, ASME Turbo Expo 2011, Vancouver, Canada.

Toal, D. J. J., Bressloff, N. W., Keane, A. J. and Holden, C., 2011, The development of a hybridized particle swarm for kriging hyperparameter tuning, Eng. Opt., 43(6): 675-699 (doi:10.1080/0305215X.2010.508524).

Wankhede, M. J., Bressloff, N. W., Keane, A. J., Caracciolo, L. and Zedda, M., 2010, An analysis of unstable flow dynamics and flashback mechanism inside a swirl-stabilised lean burn combustor, Proc. ASME Turbo Expo 2010: Power for Land, Sea and Air, GT2010-22253, 129-139, June 14-18, 2010, Glasgow, UK.

Bressloff, N. W., Mansour, M. H. and Shearman, C. P., 2010, Red blood cell migration in microvessels, Biorheology, 47(1): 73-93. Available online at http://content.iospress.com/articles/biorheology/bir560 or as author's pdf: Mansour_RBCMigrationMicrovessels_Biorheology_2010

Pant, S., Bressloff, N. W., Forrester, A. I. J. and Curzen, N., 2010, The influence of strut-connectors in stented vessels : A comparison of pulsatile flow through five different coronary stents, Annals. Biomed. Eng., 38(5): 1893-1907. Final version at Springer http://link.springer.com/article/10.1007/s10439-010-9962-0 or as author's pdf: Pant_StentStrutConnectorsHaemoFiveStents_ABME_2010

Toal, D. J. J., Bressloff, N. W., Keane, A. J. and Holden, C., 2010, Geometric filtration using POD for aerodynamic design optimization, AIAA J., 48(5): 916-928.

Holden, C., Toal, D.J.J., Bressloff, N. W. and Keane, A. J., 2010, Method of designing a structure, United States Patent US004769.

Holden, C., Nurdin, A., Bressloff, N. W. and Keane, A. J., 2010, Method of design optimisation, United States Patent US318327.

Toal, D. J. J., Forrester, A. I. J., Bressloff, N. W., Keane, A. J. and Holden, C., 2009, An adjoint for likelihood maximization, Proc. R. Soc. A, 465:3267-3287 (doi: 10.1090/rspa.2009.0096).

Pant, S. and Bressloff, N. W., 2009, Effect of strut connectors on haemodynamics of stented vessels, IFMBE Proc., World Congress on Medical Physics and Biomedical Engineering, 25:4, 680-683, Munich, Germany, 7-12 September.

Bressloff, N. W., Mansour, M. H. and Shearman, C. P., 2009, Microvascular cell depletion model, IFMBE Proc., World Congress on Medical Physics and Biomedical Engineering, 25:4, 2095-2098, Munich, Germany, 7-12 September.

Mansour, M. H., Bressloff, N. W. and Shearman, C. P., 2009, Blood flow in microvascular networks, 2nd Micro and Nano Flows Conf., West London, UK, 1-2 September.

Endicott, Giles, Keane, Andy J. and Bressloff, Neil W., 2008, Design of experiments in commericial off the shelf CFD: frameworks for efficiency. In, Conference Proceedings. 7th MIRA International Vehicle Aerodynamics Conference: Co-Relation. Nuneaton, UK, Motor Industry Research Association, 290-301.

Toal, D. J. J., Bressloff, N. W. and Keane, A. J., 2008, Kriging hyperparameter tuning strategies, AIAA J., 46(5): 1240-1252.

Toal, David J.J., Bressloff, Neil W. and Keane, Andy J., 2008, Geometric filtration using POD for aerodynamic design optimization. 26th AIAA Applied Aerodynamics Conference, Honolulu, Hawaii, 18-21 Aug 2008.

Bhaskar, K. V., Bressloff, N. W., Nair, P. B. and Shearman, C. P., 2008, Predictive haemodynamics in a one-dimensional human carotid artery bifurcation. Part II: Application to graft design, IEEE Trans. Biom. Eng., 55(3): 1176-1184.

Kolachalama, V. B., Bressloff, N. W. and Nair, P. B., 2007, Mining data from hemodynamic simulations via Bayesian emulation, BioMedical Engineering OnLine, 6:47.

Bressloff, N. W., 2007, Parametric geometry exploration in the carotid artery bifurcation, J. Biomech. , 40: 2483-2491.

Bhaskar, K. V., Bressloff, N. W., Nair, P. B. and Shearman, C. P., 2007, Predictive haemodynamics in a one-dimensional human carotid artery bifurcation. Part I: Application to stent design, IEEE Trans. Biom. Eng., 54(5): 802-812.

Banks, J. and Bressloff, N. W., 2007, Turbulence modeling in three-dimensional stenosed arterial bifurcations, ASME J. Biomech. Eng., 129: 40-50.

Ursache, N. M., Keane, A. J. and Bressloff, N. W., 2006, The design of post-buckled spinal structures for airfoil camber and shape control, AIAA J., 44(12): 3115-3124.

Hoyle, N., Bressloff, N. W. and Keane, A. J., 2006, Design Optimization of an Engine Air Intake, 2006, AIAA J., 44(11): 2672-2681.

Forrester, A. I. J., Keane, A. J. and Bressloff, N. W., 2006, Design and analysis of noisy computer experiments, 2006, AIAA J., 44(10): 2331-2339.

Pattenden, R. J., Bressloff, N. W., Turnock, S. R. and Zhang, X., 2006, LES and DES applied to the turbulent flow around a short surface-mounted cylinder, Int. J. Num. Meth. Fl. 53(6): 895-914. DOI: 10.1002/fld.1309.

Barrett, T. R., Bressloff, N. W. and Keane, A. J., 2006, Airfoil Shape Design and Optimization Using Multi-Fidelity Analysis and Embedded Inverse Design, AIAA J., 44(9): 2051-2060.

Forrester, A. I. J., Bressloff, N. W. and Keane, A. J., 2006, Optimisation using Surrogate Models and Partially Converged Computational Fluid Dynamics Simulations, , R. Soc. Proc. A. 462: 2177-2204

Barrett, T. R., Bressloff, N. W. and Keane, A. J., 2006, Airfoil Design and Optimization Using Multi-Fidelity Analysis and Embedded Inverse Design, 47th AIAA/ASME/ASCE/AHS/ASC Structures, Struc. Dyn., Mat. Conf., AIAA 2006-1820, Rhode Island, USA.

Ursache, N. M., Keane, A. J. and Bressloff, N. W., 2006, On the design of morphing airfoils using spinal structures, 47th AIAA/ASME/ASCE/AHS/ASC Structures, Struc. Dyn., Mat. Conf., AIAA 2006-1796, Rhode Island, USA.

Bhaskar, K. V., Bressloff, N. W., Nair, P. B. and Shearman, C. P., 2005, A parametric study of the hemodynamic behavior in a one dimensional systemic elastic artery: Application to stent design, 12th International Conference on BioMedical Engineering (ICBME 2005).

Sobester, A., Keane, A. J., Scanlan, J. and Bressloff, N. W., 2005, Conceptual Design of UAV Airframes Using a Generic Geometry Service , AIAA-2005-7079, Infotech@Aerospace, Arlington, VA, September 2005 .

Bressloff, N. W., Banks, J. and Shearman, C. P., 2005, Systematic exploration into the hemodynamic effect of an out-of-plane internal carotid artery , 2005 Bioengineering Conference, ASME 2005.

Bhaskar, K. V., Bressloff, N. W. and Nair, P. B., 2005, Multi-objective shape optimization of the human carotid artery, Proc. Third MIT Conference Computational Fluid and Solid Mechanics 2005. Ed. K. J. Bathe, 1310-1314, Elsevier.

Hoyle, N., Bressloff, N. W. and Keane, A. J., 2005, Design Optimization of an Engine Air Intake, Proc. Third MIT Conference Computational Fluid and Solid Mechanics 2005. Ed. K. J. Bathe, 1254-1258, Elsevier.

Stuck, Arthur, Turnock, Stephen and Bressloff, Neil (2004) An evaluation of the RANS method for the prediction of steady ship rudder performance compared to wind tunnel measurements. Southampton, UK, University of Southampton, 72pp. (Ship Science Reports, 130) http://eprints.soton.ac.uk/46049/

Forrester, A. I. J., Bressloff, N. W. and Keane, A. J., 2006, Computational Design Methods, United States Patent US7092845.

Forrester, A. I. J., Bressloff, N. W. and Keane, A. J., 2005, Design optimisation of computationally intensive design problems, European Patent EP1642222.

Bressloff, N. W., Banks, J. and Bhaskar, K. V., 2004, Parametric geometry modeling of the carotid artery bifurcation; the need for new flow metrics, Proc. Int. Workshop Flow and Motion, Zurich, Switzerland, 104-105.

Bressloff, N. W., Forrester, A. I. J., Banks, J. and Bhaskar, K. V., 2004, Shape optimization of the carotid artery bifurcation, Proc. 5th ASMO-UK/ISSMO Conf. on Engineering Design Optimisation, Stratford upon Avon, UK. Author's pdf: Bressloff_ASMO_UK_Final_2004

Ursache, N. M., Bressloff, N. W., and Keane, A. J., 2004, The design of post-buckled spinal structures for airfoil shape control using optimization methods, Proc. 5th ASMO-UK/ISSMO Conf. on Engineering Design Optimisation, Stratford upon Avon.

Bressloff, N. W., Banks, J. and Bhaskar, K. V., 2004, Parametric geometry definition and analysis of the human carotid artery bifurcation, IMECE2004-59124, ASME Mech. Eng. Cong., Anaheim, California.

Darby, S., Massimo, R., Spyropoulos, E., Bressloff, N. W. and Liliana, T., 2004, Fluvial bank erosion rates in meander bends: insights from a monitoring and modelling study in the UK and Italy, 32nd IGC, Florence, Italy.

Batten, W.M.J., Turnock, S., Bressloff, N. W. and Abu-Sharkh, S. M., 2004, Turbulent Taylor-Couette vortex flow between large radius ratio concentric cylinders. Experiments in Fluids. 36, 3: 419-421.

Pattenden, R. J., Turnock, S. R. and Bressloff, N. W., 2004, The use of detached-eddy simulation in ship hydrodynamics, 25th Symposium on Naval Hydrodynamics, St. John's, Newfoundland and Labrador, CANADA.

Forrester, A. I. J., Bressloff, N. W. and Keane, A. J., 2003, Response surface model evolution, 16th AIAA Computational Fluid Dynamics ConferenceAIAA-2003-4089, Orlanda, USA.

Pattenden, R. J., Turnock, S. R. and Bressloff, N. W., 2003, Developments in thte use of large eddy simulation for ship hydrodynamics, 3rd CFD Techniques in Ship Hydrodynamics, Royal Institute of Naval Architects, London.

Batten, W.M.J., Bressloff, N. W. and Turnock, S., 2002, Numerical simulations of the evolution of Taylor cells from a growing boundary layer on the inner cylinder of a high radius ratio Taylor-Couette system. Physical Review E. 66: (066302) 1-5.

Pattenden, R. J., Turnock, S. R. and Bressloff, N. W., 2002, An experimental and computational study of three-dimensional unsteady flow features found behind a truncated cylinder, 24th Symposium on Naval Hydrodynamics, Fukuoka, JAPAN, 208-221.

Barton, I. E., Markham-Smith, D. and Bressloff, N., 2002, Finite volume scheme for the solution of fluid flow problems on unstructured nonstaggered grids. International Journal for Numerical Methods in Fluids. 38(8): 747-768.

Batten, W., Bressloff, N. W. and Turnock, S., 2002, Transition from vortex to wall driven turbulence production in the Taylor-Couette system with a rotating inner cylinder. International Journal for Numerical Methods in Fluids. 38(3): 207-226.

Bressloff, N. W., 2001, Three-dimensional pulsatile flow through asymmetrically and symmetrically constricted vessels, BED-Vol 50, 2001 Bioengineering Conference, 525-526, ASME 2001.

Bressloff, N. W., 2001, A Parallel Pressure Implicit Splitting of Operators Algorithm Applied to Flows at all Speeds, International Journal for Numerical Methods in Fluids, 36: 497-518.

Bressloff, P. C., Bressloff, N. W. and Cowan, J. D., 2000, Dynamical mechanism for sharp orientation tuning in an integrate-and-fire model of a cortical hypercolumn. Neural Computation 12(11): 2473-2511.

Bressloff, N. W., 1999, The Influence of Soot Loading on Weighted Sum of Gray Gases Solutions to the Radiative Transfer Equation across Mixtures of Gases and Soot, International Journal of Heat and Mass Transfer , 42(18): 3469-3480.

Bressloff, P. C., Bressloff, N. W., 1999, Nonlinear dynamics of a pulse-coupled neural oscillator model of orientation tuning in the visual cortex. In AIP Conference Proceedings , 80-87.

Bressloff, P. C., Bressloff, N. W. and Cowan, J. D., Integrate-and-Fire networks and the Ring Model of Orientation tuning, presented at the Santa Fe Institute Workshop on "Understanding the Visual Cortex", April 11-15, 1999.

Bressloff, N. W.,Parallelisation of the Discrete Transfer Radiation Model, Parallel Computational Fluid Dynamics '97, eds. Ecer, A., Emerson, D., Periaux, J. and Satofuka, N., 307-316, North-Holland (1997).

Bressloff, N. W., Moss, J. B., Rubini, P.A., 1997, The Differential Total Absorptivity Solution to the Radiative Transfer Equation for Mixtures of Combustion Gases and Soot, Numerical Heat Transfer, Part B : Fundamentals, 31(1): 43-60.

Bressloff, N. W., Moss, J. B. and Rubini, P. A., 1996, CFD Prediction of Coupled Radiation Heat Transfer and Soot Production in Turbulent Flames, in : Twenty-Sixth Symposium on Combustion 2: 2379-2386, Combustion Institute, Pittsburgh, PA.

Bressloff, N. W., Moss, J. B., Rubini, P.A., 1996, Assessment of a Differential Total Absorptivity Solution to the Radiative Transfer Equation as Applied in the Discrete Transfer Radiation Model, Numerical Heat Transfer, Part B : Fundamentals, 29(3): 381-397.

Bressloff, N. W., Moss, J. B., Rubini, P.A., 1995, Application of a New Weighting Set for the Discrete Transfer Radiation Model, Proceedings of the 3rd European Conference on Industrial Furnaces and Boilers, 2: 208-215.

Cox, G, Bressloff, N. W. and Rubini, P. A., 1995, CFD Modelling of a Fire Resistance Furnace, Proc. 1st IAFSS European Symposium Zurich, Switzerland. 

Baines, N. C. and Bressloff, N., 1994, The Differential Gas Turbine Using Electric Transmission, International Gas Turbine and Aeroengine Congress and Exposition, The Hague, Netherlands, 94-GT-84, ASME.


Neil W. Bressloff

University of Southampton, Boldrewood Innovation Campus, Southampton SO16 7QF, UK. Tel. +44(0)2380 595473

Neil W. Bressloff

n.w.bressloff@soton.ac.uk


Research Projects

Heart Valve Design for Redo-TAVI. Ongoing.

Direct Metal Laser Sintering of Replacement Heart Valves. Ongoing.

Decision Support in TAVI. Ongoing.

3DVADA: 3D Visualisation and Analysis of Diseased Arteries. Ongoing.

Using Quantitative CT Imaging to Phenotype COPD. Finished.

Companies

Abbott Vascular

Arterius
Boston Scientific

Medtronic