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Research project

TCR ligand structures

Project overview

Structural characterisation of CD1 reactive T cell receptors including gamma delta and iNKT TCRs through protein crystallography

Staff

Lead researchers

Dr Salah Mansour PhD

Associate Professor

Research interests

  • Unconventioanl T cells in health and disease 
  • CD1 group 1 restricted T cell immunity  
  • Structural and molecular mechainsms of CD1 lipid antigen presentation 
Connect with Salah

Email: S.Mansour@soton.ac.uk

Other researchers

Professor Ivo Tews

Professor

Research interests

  • Natural products biosynthesis: a complex cascade of catalytic steps in vitamin B6 biosynthesis is characterised by structures or reaction intermediates in the large PLP syntase complexEdit
  • Bacterial biofilms: understanding of RedOx regulated phosphodiesterase activity in dispersal of biofilms to address chronic infections
  • Cancer immunology: together with Cancer Immunology at Southampton we use a structure based apporach in developing novel cancer therapie
Connect with Ivo

Email: Ivo.Tews@soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs